m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00048
|
[1] | |||
.png)
.png)
 : modification sites
Direct
Enhancement
m6A modification
ATP7A
ATP7A
FTO
Demethylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | Copper-transporting ATPase 1 (ATP7A) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> N1-methylguanosine (m1G) | ||||
| Epigenetic Regulator | tRNA methyltransferase 10 homolog A (TRMT10A) | WRITER | View Details | ||
| Regulated Target | Copper-transporting ATPase 1 (ATP7A) | View Details | |||
| Crosstalk Relationship | m1G → m6A | Enhancement | |||
| Crosstalk Mechanism | RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA | ||||
| Crosstalk Summary | TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (MYC; FOXD1; AUPKAIP1; Copper-transporting ATPase 1 (ATP7A) and ERCC5). | ||||
| Pathway Response | RNA degradation | hsa03018 | |||
| Cell Process | mRNA decay | ||||