m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00010
|
[1] | |||
.png)
.png)
 : m6A sites
Direct
Inhibition
RNA modification
GJC1
GJC1
ADAR1
Methylation
 : modification sites
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Gap junction gamma-1 protein (GJC1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | Gap junction gamma-1 protein (GJC1) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Inhibition | |||
| Crosstalk Mechanism | m6A modification directly impacts RNA modification through targeting the shared RNA | ||||
| Crosstalk Summary | Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Gap junction gamma-1 protein (GJC1) by reducing its m6A modification. | ||||
| Responsed Drug | Octanol | ||||
In-vitro Model |
HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| HEK293-FT | Normal | Homo sapiens | CVCL_6911 | ||
| H9 | Sezary syndrome | Homo sapiens | CVCL_1240 | ||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Gap junction gamma-1 protein (GJC1) | 1 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
 Compound Name |
octanol | Investigative | [2] | |
|---|---|---|---|---|
| Synonyms |
1-octanol; Octan-1-ol; 111-87-5; N-octanol; Capryl alcohol; Octyl alcohol; caprylic alcohol; n-Octyl alcohol; Heptyl carbinol; 1-Hydroxyoctane; Primary octyl alcohol; Alcohol C-8; n-Octan-1-ol; Octilin; Sipol L8; Alfol 8; Lorol 20; Dytol M-83; n-Caprylic alcohol; 1-Octyl alcohol; n-Heptyl carbinol; EPAL 8; octyl-alcohol; Alcohols, C6-12; N-octyl-alcohol; Octyl alcohol, normal-primary; C8 alcohol; Fatty alcohol(C8); Octyl alcohol, primary; Caswell No. 611A; Octyl alcohol (natural); FEMA Number 2800; Lorol C 8-98; n-Capryl alcohol
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
References