m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00788)
Target Name LOC10013.776 (AGAP2-AS1)
Synonyms
LOC10013.776; PUNISHER
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Gene Name AGAP2-AS1
Chromosomal Location 12q14.1
Gene ID 100130776
HGNC ID
HGNC:48633
Ensembl Gene ID
ENSG00000255737
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
AGAP2-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between AGAP2-AS1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.67E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation.
Target Regulation Up regulation
Responsed Disease Psoriasis ICD-11: EA90
 Disease Info 
Pathway Response mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151),
Cell Process Cell proliferation
In-vitro Model HaCaT Normal Homo sapiens CVCL_0038
NHEK (Normal human epithelial keratinocytes)
Psoriasis [ICD-11: EA90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation.
Responsed Disease Psoriasis [ICD-11: EA90]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151),
Cell Process Cell proliferation
In-vitro Model HaCaT Normal Homo sapiens CVCL_0038
NHEK (Normal human epithelial keratinocytes)
References
Ref 1 N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p/AKT3 axis. J Dermatol Sci. 2022 Jan;105(1):27-36. doi: 10.1016/j.jdermsci.2021.11.007. Epub 2021 Nov 18.