m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00767)
Target Name Guanine nucleotide-binding protein G (GNAS)
Synonyms
GNAS1; Guanine nucleotide-binding protein G; s subunit alpha isoforms XLas ; Adenylate cyclase-stimulating G alpha protein ; Extra large alphas protein; XLalphas
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Gene Name GNAS
Chromosomal Location 20q13.32
Family G-alpha family, G(s) subfamily
Function
FUNCTION: cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).
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Gene ID 2778
Uniprot ID
GNAS1_HUMAN
HGNC ID
HGNC:4392
Ensembl Gene ID
ENSG00000087460.29
KEGG ID
#N/A
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
GNAS can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 promotes tumor growth and hormone secretion by increasing expression of Guanine nucleotide-binding protein G (GNAS) and GADD45-Gamma in a m6A-dependent manner. Thus, METTL3 and the methylated RNAs constitute suitable targets for clinical treatment of Pituitary growth hormone-secreting-pituitary adenomas(GH-PAs).
Target Regulation Up regulation
Responsed Disease Endocrine glands benign cancer ICD-11: 2F37
 Disease Info 
Endocrine glands benign cancer [ICD-11: 2F37]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 promotes tumor growth and hormone secretion by increasing expression of Guanine nucleotide-binding protein G (GNAS) and GADD45-Gamma in a m6A-dependent manner. Thus, METTL3 and the methylated RNAs constitute suitable targets for clinical treatment of Pituitary growth hormone-secreting-pituitary adenomas(GH-PAs).
Responsed Disease Endocrine glands benign cancer [ICD-11: 2F37]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
References
Ref 1 METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas. J Clin Endocrinol Metab. 2022 Jan 1;107(1):136-149. doi: 10.1210/clinem/dgab652.