m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00766)
Target Name L-glutamine amidohydrolase (GLS2)
Synonyms
GA; Glutaminase liver isoform; mitochondrial; GLS; EC 3.5.1.2 ; L-glutaminase ; L-glutamine amidohydrolase
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Gene Name GLS2
Chromosomal Location 12q13.3
Family Glutaminase family
Function
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
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Gene ID 27165
Uniprot ID
GLSL_HUMAN
HGNC ID
HGNC:29570
Ensembl Gene ID
ENSG00000135423.13
KEGG ID
hsa:27165
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
GLS2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between GLS2 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 5.89E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary L-glutamine amidohydrolase (GLS2) as a downstream target of METTL3. These findings uncover METTL3/GLS2 signaling as a potential therapeutic target in antimetastatic strategies against esophageal Squamous Cell Carcinoma(ESCC).
Target Regulation Up regulation
Responsed Disease Esophageal squamous cell carcinoma ICD-11: 2B70.1
 Disease Info 
Cell Process Cell migration
Cell invasion
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
TE-13 Esophageal squamous cell carcinoma Homo sapiens CVCL_4463
Eca-109 Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
EC/CUHK1 Esophageal carcinoma Homo sapiens CVCL_RY08
Oral cavity/oesophagus/stomach in situ carcinoma [ICD-11: 2E60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary L-glutamine amidohydrolase (GLS2) as a downstream target of METTL3. These findings uncover METTL3/GLS2 signaling as a potential therapeutic target in antimetastatic strategies against esophageal Squamous Cell Carcinoma(ESCC).
Responsed Disease Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell migration
Cell invasion
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
TE-13 Esophageal squamous cell carcinoma Homo sapiens CVCL_4463
Eca-109 Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
EC/CUHK1 Esophageal carcinoma Homo sapiens CVCL_RY08
References
Ref 1 METTL3 Promotes Esophageal Squamous Cell Carcinoma Metastasis Through Enhancing GLS2 Expression. Front Oncol. 2021 May 19;11:667451. doi: 10.3389/fonc.2021.667451. eCollection 2021.