m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00765)
Target Name Cytokine-responsive protein CR6 (GADD45-Gamma)
Synonyms
CR6; DDIT2; Growth arrest and DNA damage-inducible protein GADD45 gamma ; Cytokine-responsive protein CR6 ; DNA damage-inducible transcript 2 protein; DDIT-2
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Gene Name GADD45-Gamma
Chromosomal Location 9q22.2
Family GADD45 family
Function
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
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Gene ID 10912
Uniprot ID
GA45G_HUMAN
HGNC ID
HGNC:4097
Ensembl Gene ID
ENSG00000130222.11
KEGG ID
hsa:10912
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
GADD45-Gamma can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 promotes tumor growth and hormone secretion by increasing expression of GNAS and Cytokine-responsive protein CR6 (GADD45-Gamma) in a m6A-dependent manner. Thus, METTL3 and the methylated RNAs constitute suitable targets for clinical treatment of Pituitary growth hormone-secreting-pituitary adenomas(GH-PAs).
Target Regulation Up regulation
Responsed Disease Endocrine glands benign cancer ICD-11: 2F37
 Disease Info 
Endocrine glands benign cancer [ICD-11: 2F37]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 promotes tumor growth and hormone secretion by increasing expression of GNAS and Cytokine-responsive protein CR6 (GADD45-Gamma) in a m6A-dependent manner. Thus, METTL3 and the methylated RNAs constitute suitable targets for clinical treatment of Pituitary growth hormone-secreting-pituitary adenomas(GH-PAs).
Responsed Disease Endocrine glands benign cancer [ICD-11: 2F37]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
References
Ref 1 METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas. J Clin Endocrinol Metab. 2022 Jan 1;107(1):136-149. doi: 10.1210/clinem/dgab652.