m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00760)
Target Name Monocyte chemotactic and activating factor (CCL2)
Synonyms
MCP1; SCYA2; C-C motif chemokine 2 ; HC11 ; Monocyte chemoattractant protein 1 ; Monocyte chemotactic and activating factor; MCAF ; Monocyte chemotactic protein 1; MCP-1 ; Monocyte secretory protein JE ; Small-inducible cytokine A2
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Gene Name Ccl2
Chromosomal Location 17q12
Family Intercrine beta (chemokine CC) family
Function
Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
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Gene ID 6347
Uniprot ID
CCL2_HUMAN
HGNC ID
HGNC:10618
Ensembl Gene ID
ENSG00000108691.9
KEGG ID
hsa:6347
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Ccl2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between Ccl2 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 4.91E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Mechanistically, METTL3 directly binds to the promoters of the Cd36 and Monocyte chemotactic and activating factor (CCL2) genes and recruits HDAC1/2 to induce deacetylation of H3K9 and H3K27 in their promoters, thus suppressing Cd36 and Ccl2 transcription. METTL3 negatively regulates hepatic Cd36 and Ccl2 gene transcription via a histone modification pathway for protection against Nonalcoholic steatohepatitis(NASH) progression.
Target Regulation Down regulation
Responsed Disease Nonalcoholic steatohepatitis ICD-11: DB92.1
 Disease Info 
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model Mettl3flox/flox and Mettl3-HKO mice were fasted overnight and then injected intraperitoneally with 20 uM BODIPY FL C16 in 200 ul saline for 20 min.
Non-alcoholic fatty liver disease [ICD-11: DB92]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Mechanistically, METTL3 directly binds to the promoters of the Cd36 and Monocyte chemotactic and activating factor (CCL2) genes and recruits HDAC1/2 to induce deacetylation of H3K9 and H3K27 in their promoters, thus suppressing Cd36 and Ccl2 transcription. METTL3 negatively regulates hepatic Cd36 and Ccl2 gene transcription via a histone modification pathway for protection against Nonalcoholic steatohepatitis(NASH) progression.
Responsed Disease Nonalcoholic steatohepatitis [ICD-11: DB92.1]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model Mettl3flox/flox and Mettl3-HKO mice were fasted overnight and then injected intraperitoneally with 20 uM BODIPY FL C16 in 200 ul saline for 20 min.
References
Ref 1 The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. Nat Commun. 2021 Dec 10;12(1):7213. doi: 10.1038/s41467-021-27539-3.