m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00759)
Target Name Chromobox protein homolog 8 (CBX8)
Synonyms
PC3; RC1; Chromobox protein homolog 8 ; Polycomb 3 homolog; Pc3; hPc3 ; Rectachrome 1
    Click to Show/Hide
Gene Name CBX8
Chromosomal Location 17q25.3
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
    Click to Show/Hide
Gene ID 57332
Uniprot ID
CBX8_HUMAN
HGNC ID
HGNC:15962
Ensembl Gene ID
ENSG00000141570.11
KEGG ID
hsa:57332
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CBX8 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Colon cancer [ICD-11: 2B90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary m6A methylation participated in the upregulation of CBX8 by maintaining Chromobox protein homolog 8 (CBX8) mRNA stability. Upon m6A methylation-induced upregulation, CBX8 interacts with KMT2b and Pol II to promote LGR5 expression in a noncanonical manner, which contributes to increased cancer stemness and decreased chemosensitivity in colon cancer.
Responsed Disease Colon cancer [ICD-11: 2B90]
Cell Process Stemness property
In-vitro Model ()
()
()
()
()
()
()
()
In-vivo Model Xenograft tumor formation was observed in 5 of 5 and 3 of 5 animals when 1 × 105 and 1 × 104 sorted LGR5+ cells, were subcutaneously injected into nude mice, respectively