m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00756)
Target Name Beta-site APP-cleaving enzyme 2 (BACE2)
Synonyms
AEPLC; ALP56; ASP21; Beta-secretase 2; EC 3.4.23.45 ; Aspartic-like protease 56 kDa ; Aspartyl protease 1; ASP1; Asp 1 ; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2 ; Down region aspartic protease; DRAP ; Memapsin-1 ; Membrane-associated aspartic protease 1 ; Theta-secretase
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Gene Name BACE2
Chromosomal Location 21q22.2-q22.3
Family Peptidase A1 family
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
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Gene ID 25825
Uniprot ID
BACE2_HUMAN
HGNC ID
HGNC:934
Ensembl Gene ID
ENSG00000182240.16
KEGG ID
hsa:25825
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
BACE2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Melanoma [ICD-11: 2C30]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Beta-site APP-cleaving enzyme 2 (BACE2) presented an increased level of N6-methyladenosine (m6A) RNA methylation, which led to the upregulation of BACE2 mRNA. This study provides a novel pattern of BACE2-mediated intracellular calcium release in ocular melanoma progression.
Responsed Disease Melanoma of uvea [ICD-11: 2D0Y]
Cell Process Intracellular calcium release
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