m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00745)
Target Name Metalloproteinase inhibitor 1 (TIMP-1)
Synonyms
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
    Click to Show/Hide
Gene Name TIMP-1
Chromosomal Location Xp11.3
Family Protease inhibitor I35 (TIMP) family
Function
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
    Click to Show/Hide
Gene ID 7076
Uniprot ID
TIMP1_HUMAN
HGNC ID
HGNC:11820
Ensembl Gene ID
ENSG00000102265
KEGG ID
hsa:7076
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TIMP-1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line LX2 cell line Homo sapiens
Treatment: shMETTL3 LX2 cells
Control: shLuc LX2 cells
 GSE207909
Regulation
logFC: -1.77E+00
p-value: 2.62E-61
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between TIMP-1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 2.26E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 is involved in OA probably by regulating the inflammatory response. METTL3 overexpression affects extracellular matrix degradation in OA by adjusting the balance between Metalloproteinase inhibitor 1 (TIMP-1) and MMPs.
Target Regulation Down regulation
Responsed Disease Osteoarthritis ICD-11: FA05
 Disease Info 
Cell Process Inflammatory response
In-vitro Model SW1353 Primary central chondrosarcoma Homo sapiens CVCL_0543
Osteoarthritis [ICD-11: FA05]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 is involved in OA probably by regulating the inflammatory response. METTL3 overexpression affects extracellular matrix degradation in OA by adjusting the balance between Metalloproteinase inhibitor 1 (TIMP-1) and MMPs.
Responsed Disease Osteoarthritis [ICD-11: FA05]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Inflammatory response
In-vitro Model SW1353 Primary central chondrosarcoma Homo sapiens CVCL_0543
References
Ref 1 METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response. Life Sci. 2021 Aug 1;278:119528. doi: 10.1016/j.lfs.2021.119528. Epub 2021 Apr 21.