m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00701)
Target Name Abnormal spindle-like microcephaly-associated protein (ASPM)
Synonyms
Abnormal spindle protein homolog; Asp homolog
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Gene Name ASPM
Chromosomal Location 1q31.3
Function
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.
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Gene ID 259266
Uniprot ID
ASPM_HUMAN
HGNC ID
HGNC:19048
Ensembl Gene ID
ENSG00000066279
KEGG ID
hsa:259266
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ASPM can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Mouse testis Mus musculus
Treatment: Mettl3 knockout mouse testis
Control: Mouse testis
 GSE99771
Regulation
logFC: -3.99E+00
p-value: 5.74E-06
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between ASPM and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.27E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The N6-methyladenosine (m6A) modification of ASPM mRNA mediated by METTL3 promoted its expression in liver hepatocellular carcinoma.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Cell Process Cells growth
Cell metastasis
In-vitro Model SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
Hepg3b (Hepg3b were purchased from the American Type Culture Collection (ATCC, USA))
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The N6-methyladenosine (m6A) modification of ASPM mRNA mediated by METTL3 promoted its expression in liver hepatocellular carcinoma.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cells growth
Cell metastasis
In-vitro Model SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
Hepg3b (Hepg3b were purchased from the American Type Culture Collection (ATCC, USA))
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
References
Ref 1 METTL3-mediated m6A methylation of ASPM drives hepatocellular carcinoma cells growth and metastasis. J Clin Lab Anal. 2021 Sep;35(9):e23931. doi: 10.1002/jcla.23931. Epub 2021 Aug 16.