m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00696)
Target Name Cadherin-1 (CDH1)
Synonyms
CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324
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Gene Name CDH1
Chromosomal Location 16q22.1
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production; (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
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Gene ID 999
Uniprot ID
CADH1_HUMAN
HGNC ID
HGNC:1748
Ensembl Gene ID
ENSG00000039068
KEGG ID
hsa:999
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CDH1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -7.84E-01
p-value: 1.59E-117
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between CDH1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 4.00E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary PM2.5 exposure increased the levels of METTL3-mediated m6A modification of Cadherin-1 (CDH1) mRNA. PM2.5 exposure triggered EMT progression to promote the pulmonary fibrosis via miR-494-3p/YTHDF2 recognized and METTL3 mediated m6A modification.
Responsed Disease Pulmonary Fibrosis ICD-11: CB03.4
 Disease Info 
Pathway Response Adherens junction hsa04520
Cell Process Epithelial-mesenchymal transition
Idiopathic interstitial pneumonitis [ICD-11: CB03]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary PM2.5 exposure increased the levels of METTL3-mediated m6A modification of Cadherin-1 (CDH1) mRNA. PM2.5 exposure triggered EMT progression to promote the pulmonary fibrosis via miR-494-3p/YTHDF2 recognized and METTL3 mediated m6A modification.
Responsed Disease Pulmonary Fibrosis [ICD-11: CB03.4]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Pathway Response Adherens junction hsa04520
Cell Process Epithelial-mesenchymal transition
References
Ref 1 N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition. Toxicol Sci. 2022 Jan 24;185(2):143-157. doi: 10.1093/toxsci/kfab133.