m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00604)
Target Name Nuclear receptor-interacting protein 1 (NRIP1)
Synonyms
Nuclear factor RIP140; Receptor-interacting protein 140
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Gene Name NRIP1
Chromosomal Location 21q11.2-q21.1
Function
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development.
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Gene ID 8204
Uniprot ID
NRIP1_HUMAN
HGNC ID
HGNC:8001
Ensembl Gene ID
ENSG00000180530
KEGG ID
hsa:8204
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
NRIP1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line DKO-1 cell line Homo sapiens
Treatment: METTL3 knockdown DKO-1 cell
Control: DKO-1 cell
 GSE182382
Regulation
logFC: -1.29E+00
p-value: 1.52E-02
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between NRIP1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 2.30E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The NRIP1 mRNA increased in fetal brain tissues of DS, whereas the m6A modification of the NRIP1 mRNA significantly decreased. METTL3 knockdown reduced the m6A modification of NRIP1 mRNA and increased its expression, and an increase in NRIP1 m6A modification and a decrease in its expression were observed in METTL3-overexpressed cells.
Target Regulation Down regulation
Responsed Disease Complete trisomy 21 ICD-11: LD40.0
 Disease Info 
In-vitro Model HT22 Normal Mus musculus CVCL_0321
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HEK293T Normal Homo sapiens CVCL_0063
Down syndrome [ICD-11: LD40]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The NRIP1 mRNA increased in fetal brain tissues of DS, whereas the m6A modification of the NRIP1 mRNA significantly decreased. METTL3 knockdown reduced the m6A modification of NRIP1 mRNA and increased its expression, and an increase in NRIP1 m6A modification and a decrease in its expression were observed in METTL3-overexpressed cells.
Responsed Disease Complete trisomy 21 [ICD-11: LD40.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model HT22 Normal Mus musculus CVCL_0321
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HEK293T Normal Homo sapiens CVCL_0063
References
Ref 1 METTL3-Mediated N6-Methyladenosine Modification Is Involved in the Dysregulation of NRIP1 Expression in Down Syndrome. Front Cell Dev Biol. 2021 Apr 1;9:621374. doi: 10.3389/fcell.2021.621374. eCollection 2021.