m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00597)
Target Name Collagen alpha-1 (III) chain (COL3A1)
Gene Name COL3A1
Chromosomal Location 2q32.2
Family Fibrillar collagen family
Function
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
    Click to Show/Hide
Gene ID 1281
Uniprot ID
CO3A1_HUMAN
HGNC ID
HGNC:2201
Ensembl Gene ID
ENSG00000168542
KEGG ID
hsa:1281
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
COL3A1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: 2.13E+00
p-value: 6.01E-268
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between COL3A1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 3.39E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 could down-regulate the expression of Collagen alpha-1 (III) chain (COL3A1) by increasing its m6A methylation, ultimately inhibiting the metastasis of TNBC cells.
Target Regulation Down regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
In-vitro Model MDA-MB-468 Breast adenocarcinoma Homo sapiens CVCL_0419
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 could down-regulate the expression of Collagen alpha-1 (III) chain (COL3A1) by increasing its m6A methylation, ultimately inhibiting the metastasis of TNBC cells.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model MDA-MB-468 Breast adenocarcinoma Homo sapiens CVCL_0419
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
References
Ref 1 Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation. Front Oncol. 2020 Jul 14;10:1126. doi: 10.3389/fonc.2020.01126. eCollection 2020.