m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00578)
Target Name Thioredoxin domain-containing protein 5 (TXNDC5)
Synonyms
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
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Gene Name TXNDC5
Chromosomal Location 6p24.3
Family Protein disulfide isomerase family
Function
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
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Gene ID 81567
Uniprot ID
TXND5_HUMAN
HGNC ID
HGNC:21073
Ensembl Gene ID
ENSG00000239264
KEGG ID
hsa:81567
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TXNDC5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line LX2 cell line Homo sapiens
Treatment: shMETTL3 LX2 cells
Control: shLuc LX2 cells
 GSE207909
Regulation
logFC: -6.19E-01
p-value: 4.11E-14
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 regulates certain m6A-methylated transcripts, Thioredoxin domain-containing protein 5 (TXNDC5), targeting the m6A dependent-METTL3 signaling pathway serves as a promising therapeutic strategy for management of patients of acral melanomas.
Target Regulation Up regulation
Responsed Disease Melanoma ICD-11: 2C30
 Disease Info 
Cell Process Cell proliferation, cell migration,cell invasion
In-vitro Model SK-MEL-28 Cutaneous melanoma Homo sapiens CVCL_0526
MV3 Amelanotic melanoma Homo sapiens CVCL_W280
HMY-1 Melanoma Homo sapiens CVCL_2950
HEMa (The normal human epidermal melanocyte (HEMa) was extracted from fresh foreskin tissue donated after circumcision in adults and cultured in melanocyte medium with 5% fetal bovine serum (Sciencell, USA))
A-875 Melanoma Homo sapiens CVCL_4733
A375-MA2 Amelanotic melanoma Homo sapiens CVCL_X495
A2058 Amelanotic melanoma Homo sapiens CVCL_1059
In-vivo Model Sixteen BALB/c nude mice (male, 6-week-old) were raised under pathogen-free conditions and randomly divided into two groups. A total of 2 × 106 A375 NTC or sh-METTL3#2 cells were subcutaneously inoculated into the right hind flank. Body weight and tumor size were measured every other day. The tumors were harvested at the end of the observation period, and tumor weight and gross images were recorded (11 days after inoculation). The tumors were embedded in RNA later and 10% formalin for further detection.
Melanoma [ICD-11: 2C30]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 regulates certain m6A-methylated transcripts, Thioredoxin domain-containing protein 5 (TXNDC5), targeting the m6A dependent-METTL3 signaling pathway serves as a promising therapeutic strategy for management of patients of acral melanomas.
Responsed Disease Melanoma [ICD-11: 2C30]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation, cell migration,cell invasion
In-vitro Model SK-MEL-28 Cutaneous melanoma Homo sapiens CVCL_0526
MV3 Amelanotic melanoma Homo sapiens CVCL_W280
HMY-1 Melanoma Homo sapiens CVCL_2950
HEMa (The normal human epidermal melanocyte (HEMa) was extracted from fresh foreskin tissue donated after circumcision in adults and cultured in melanocyte medium with 5% fetal bovine serum (Sciencell, USA))
A-875 Melanoma Homo sapiens CVCL_4733
A375-MA2 Amelanotic melanoma Homo sapiens CVCL_X495
A2058 Amelanotic melanoma Homo sapiens CVCL_1059
In-vivo Model Sixteen BALB/c nude mice (male, 6-week-old) were raised under pathogen-free conditions and randomly divided into two groups. A total of 2 × 106 A375 NTC or sh-METTL3#2 cells were subcutaneously inoculated into the right hind flank. Body weight and tumor size were measured every other day. The tumors were harvested at the end of the observation period, and tumor weight and gross images were recorded (11 days after inoculation). The tumors were embedded in RNA later and 10% formalin for further detection.
References
Ref 1 m(6)A Methyltransferase METTL3 Promotes the Progression of Primary Acral Melanoma via Mediating TXNDC5 Methylation. Front Oncol. 2022 Jan 18;11:770325. doi: 10.3389/fonc.2021.770325. eCollection 2021.