m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00536)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ADAR1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | E14.5 LSK cell line | Mus musculus |
Treatment: METTL3 knockout E14.5 LSK cells
Control: Wild type E14.5 LSK cells
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GSE148882 | |
Regulation |
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logFC: 6.03E-01 p-value: 6.54E-18 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3, upregulated in glioblastoma, methylates Interferon-inducible protein 4 (ADAR1) mRNA and increases its protein level leading to a pro-tumorigenic mechanism connecting METTL3, YTHDF1, and ADAR1. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Glioblastoma | ICD-11: 2A00.00 | ||
Pathway Response | mRNA surveillance pathway | hsa03015 | ||
RNA degradation | hsa03018 | |||
Cell Process | RNA stability | |||
In-vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 |
U-118MG | Astrocytoma | Homo sapiens | CVCL_0633 | |
T98G | Glioblastoma | Homo sapiens | CVCL_0556 | |
A-172 | Glioblastoma | Homo sapiens | CVCL_0131 | |
In-vivo Model | 2 × 106 U87MG cells already expressing shscr or shADAR1 were subcutaneously injected in the flank of 6-week-old nude mice (nu/nu, Charles River, Wilmington, MA, USA). | |||
Brain cancer [ICD-11: 2A00]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3, upregulated in glioblastoma, methylates Interferon-inducible protein 4 (ADAR1) mRNA and increases its protein level leading to a pro-tumorigenic mechanism connecting METTL3, YTHDF1, and ADAR1. | |||
Responsed Disease | Glioblastoma [ICD-11: 2A00.00] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Pathway Response | mRNA surveillance pathway | hsa03015 | ||
RNA degradation | hsa03018 | |||
Cell Process | RNA stability | |||
In-vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 |
U-118MG | Astrocytoma | Homo sapiens | CVCL_0633 | |
T98G | Glioblastoma | Homo sapiens | CVCL_0556 | |
A-172 | Glioblastoma | Homo sapiens | CVCL_0131 | |
In-vivo Model | 2 × 106 U87MG cells already expressing shscr or shADAR1 were subcutaneously injected in the flank of 6-week-old nude mice (nu/nu, Charles River, Wilmington, MA, USA). | |||