m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00530)
Target Name Stromelysin-1 (MMP-3)
Synonyms
SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1
    Click to Show/Hide
Gene Name MMP-3
Chromosomal Location 11q22.2
Family Peptidase M10A family
Function
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
    Click to Show/Hide
Gene ID 4314
Uniprot ID
MMP3_HUMAN
HGNC ID
HGNC:7173
Ensembl Gene ID
ENSG00000149968
KEGG ID
hsa:4314
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MMP-3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line HUVEC cell line Homo sapiens
Treatment: shMETTL3 HUVEC cells
Control: shScramble HUVEC cells
 GSE157544
Regulation
logFC: -1.52E+00
p-value: 7.27E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knockdown suppressed interleukin (IL)-6, matrix metalloproteinase Stromelysin-1 (MMP-3), and MMP-9 levels in human RA-FLSs and rat AIA-FLSs.
Target Regulation Up regulation
Responsed Disease Rheumatoid arthritis ICD-11: FA20
 Disease Info 
Cell Process Inflammatory response
In-vitro Model FLS (Rat fibroblast synovial cell line)
In-vivo Model To establish the adjuvant-induced arthritis (AIA) model, the rats were given complete Freund's adjuvant (CFA; Chondrex, Inc.) on the left paw of 0.1 ml per 100 g of body weight. Additionally, the rats were injected with normal saline to create the negative control (NC) group.
Rheumatoid arthritis [ICD-11: FA20]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knockdown suppressed interleukin (IL)-6, matrix metalloproteinase Stromelysin-1 (MMP-3), and MMP-9 levels in human RA-FLSs and rat AIA-FLSs.
Responsed Disease Rheumatoid arthritis [ICD-11: FA20]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Inflammatory response
In-vitro Model FLS (Rat fibroblast synovial cell line)
In-vivo Model To establish the adjuvant-induced arthritis (AIA) model, the rats were given complete Freund's adjuvant (CFA; Chondrex, Inc.) on the left paw of 0.1 ml per 100 g of body weight. Additionally, the rats were injected with normal saline to create the negative control (NC) group.
References
Ref 1 METTL3 Promotes Activation and Inflammation of FLSs Through the NF-KappaB Signaling Pathway in Rheumatoid Arthritis. Front Med (Lausanne). 2021 Jul 6;8:607585. doi: 10.3389/fmed.2021.607585. eCollection 2021.