m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00480)
Target Name Wilms tumor protein (WT1)
Synonyms
WT33
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Gene Name WT1
Family EGR C2H2-type zinc-finger protein family. {ECO:0000305}.
Function
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
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Gene ID 55083
Uniprot ID
WT1_HUMAN
HGNC ID
HGNC:12796
Ensembl Gene ID
ENSG00000184937
KEGG ID
hsa:7490
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
WT1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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ETS-related transcription factor Elf-3 (ELF3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Elf3 plays an important role in the process of phenotypic alterations of podocyte induced by the activation of TGF-beta signals. Elf3 protein levels in patients with DN (R2 = 0.7259) were useful as an early non-invasive marker for podocyte injuries in DN. The epithelium-specific transcription factor, Elf3 was induced by AGE stimulation and, subsequently, upregulated RII expression in cultured podocytes. Induction of Elf3 and activation of RII-Smad3 signaling, leading to a decrease in Wilms tumor protein (WT1) expression, were observed in podocytes in diabetic human kidneys.
Responsed Disease Chronic kidney disease ICD-11: GB61.Z
 Disease Info 
Pathway Response TGF-beta signaling pathway hsa04350
In-vitro Model Murine podocytes Normal Mus musculus CVCL_5737
Chronic kidney disease [ICD-11: GB61]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Elf3 plays an important role in the process of phenotypic alterations of podocyte induced by the activation of TGF-beta signals. Elf3 protein levels in patients with DN (R2 = 0.7259) were useful as an early non-invasive marker for podocyte injuries in DN. The epithelium-specific transcription factor, Elf3 was induced by AGE stimulation and, subsequently, upregulated RII expression in cultured podocytes. Induction of Elf3 and activation of RII-Smad3 signaling, leading to a decrease in Wilms tumor protein (WT1) expression, were observed in podocytes in diabetic human kidneys.
Responsed Disease Chronic kidney disease [ICD-11: GB61.Z]
Target Regulator ETS-related transcription factor Elf-3 (ELF3) WRITER
 Regulator Info 
Pathway Response TGF-beta signaling pathway hsa04350
In-vitro Model Murine podocytes Normal Mus musculus CVCL_5737
References
Ref 1 Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy. PLoS One. 2019 May 31;14(5):e0216788. doi: 10.1371/journal.pone.0216788. eCollection 2019.