m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00434)
Target Name Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Gene Name TNFRSF10A
Chromosomal Location 8p21.3
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
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Gene ID 8797
Uniprot ID
TR10A_HUMAN
HGNC ID
HGNC:11904
Ensembl Gene ID
ENSG00000104689
KEGG ID
hsa:8797
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TNFRSF10A can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Wilms tumor 1-associating protein (WTAP) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by WTAP
Cell Line Human umbilical vein endothelial cells Homo sapiens
Treatment: siWTAP HUVECs
Control: siControl HUVECs
 GSE167067
Regulation
logFC: 1.73E+00
p-value: 1.15E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary This study established the transcriptional map of m6A in MH7A cells and revealed the potential relationship between RNA methylation modification and rheumatoid arthritis related genes. The results suggested that m6A modification was associated with the occurrence and course of RA to some extent. The validations of WTAP, RIPK2, JAK3 and Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) were in accordance with the m6A and RNA sequencing results.
Responsed Disease Rheumatoid arthritis ICD-11: FA20
 Disease Info 
Pathway Response JAK-STAT signaling pathway hsa04630
Cytokine-cytokine receptor interaction hsa04060
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model MH7A Normal Homo sapiens CVCL_0427
In-vivo Model The rats were adaptively fed for 1 week and then subcutaneous injection of complete Freund's adjuvant into the left hindfoot toe to establish an adjuvant arthritis (AA) rat model. After induction of the immune response for 20 days, all rats were anesthetized by the intraperitoneal injection of 1% sodium pentobarbital (60 mg/kg) and sacrificed by exsanguination of the abdominal aorta.
Rheumatoid arthritis [ICD-11: FA20]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary This study established the transcriptional map of m6A in MH7A cells and revealed the potential relationship between RNA methylation modification and rheumatoid arthritis related genes. The results suggested that m6A modification was associated with the occurrence and course of RA to some extent. The validations of WTAP, RIPK2, JAK3 and Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) were in accordance with the m6A and RNA sequencing results.
Responsed Disease Rheumatoid arthritis [ICD-11: FA20]
Target Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
Pathway Response JAK-STAT signaling pathway hsa04630
Cytokine-cytokine receptor interaction hsa04060
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model MH7A Normal Homo sapiens CVCL_0427
In-vivo Model The rats were adaptively fed for 1 week and then subcutaneous injection of complete Freund's adjuvant into the left hindfoot toe to establish an adjuvant arthritis (AA) rat model. After induction of the immune response for 20 days, all rats were anesthetized by the intraperitoneal injection of 1% sodium pentobarbital (60 mg/kg) and sacrificed by exsanguination of the abdominal aorta.
References
Ref 1 Transcriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A. J Inflamm Res. 2021 Feb 25;14:575-586. doi: 10.2147/JIR.S296006. eCollection 2021.