m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00407)
Target Name Transcription factor Sp2 (SP2)
Synonyms
KIAA0048
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Gene Name SP2
Chromosomal Location 17q21.32
Family Sp1 C2H2-type zinc-finger protein family
Function
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
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Gene ID 6668
Uniprot ID
SP2_HUMAN
HGNC ID
HGNC:11207
Ensembl Gene ID
ENSG00000167182
KEGG ID
hsa:6668
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
 GSE155612
Regulation
logFC: 8.11E-01
p-value: 3.84E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors SP1 and Transcription factor Sp2 (SP2), which have promoters occupied by METTL3.
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Cell Process Cell cycle
In-vitro Model EoL-1 Chronic eosinophilic leukemia Homo sapiens CVCL_0258
HEL Erythroleukemia Homo sapiens CVCL_0001
HL-60 Adult acute myeloid leukemia Homo sapiens CVCL_0002
Jurkat T acute lymphoblastic leukemia Homo sapiens CVCL_0065
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
KG-1 Adult acute myeloid leukemia Homo sapiens CVCL_0374
Loucy Adult T acute lymphoblastic leukemia Homo sapiens CVCL_1380
MOLM-13 Adult acute myeloid leukemia Homo sapiens CVCL_2119
MV4-11 Childhood acute monocytic leukemia Homo sapiens CVCL_0064
NOMO-1 Adult acute monocytic leukemia Homo sapiens CVCL_1609
RN2c (Acute myeloid leukemia cell line)
THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
In-vivo Model Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication.
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors SP1 and Transcription factor Sp2 (SP2), which have promoters occupied by METTL3.
Responsed Disease Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Cell Process Cell cycle
In-vitro Model EoL-1 Chronic eosinophilic leukemia Homo sapiens CVCL_0258
HEL Erythroleukemia Homo sapiens CVCL_0001
HL-60 Adult acute myeloid leukemia Homo sapiens CVCL_0002
Jurkat T acute lymphoblastic leukemia Homo sapiens CVCL_0065
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
KG-1 Adult acute myeloid leukemia Homo sapiens CVCL_0374
Loucy Adult T acute lymphoblastic leukemia Homo sapiens CVCL_1380
MOLM-13 Adult acute myeloid leukemia Homo sapiens CVCL_2119
MV4-11 Childhood acute monocytic leukemia Homo sapiens CVCL_0064
NOMO-1 Adult acute monocytic leukemia Homo sapiens CVCL_1609
RN2c (Acute myeloid leukemia cell line)
THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
In-vivo Model Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication.
References
Ref 1 Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.