m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00383)
Target Name Rho GTPase-activating protein 7 (DLC1)
Synonyms
Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12; ARHGAP7; KIAA1723; STARD12
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Gene Name DLC1
Chromosomal Location 8p22
Function
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
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Gene ID 10395
Uniprot ID
RHG07_HUMAN
HGNC ID
HGNC:2897
Ensembl Gene ID
ENSG00000164741
KEGG ID
hsa:10395
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DLC1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary In lung squamous cell carcinoma, seven m6A-related autophagy genes were screened to construct a prognostic model: CASP4, CDKN1A, Rho GTPase-activating protein 7 (DLC1), ITGB1, PINK1, TP63, and EIF4EBP1.
Responsed Disease Lung squamous cell carcinoma [ICD-11: 2C25.2]
Pathway Response Autophagy hsa04140
Cell Process Cell proliferation and metastasis
Cell autophagy