m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00376)
Target Name Parathyroid hormone 1 receptor (PTH1R)
Synonyms
PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTHR; PTHR1
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Gene Name PTH1R
Chromosomal Location 3p21.31
Family G-protein coupled receptor 2 family
Function
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
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Gene ID 5745
Uniprot ID
PTH1R_HUMAN
HGNC ID
HGNC:9608
Ensembl Gene ID
ENSG00000160801
KEGG ID
hsa:5745
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PTH1R can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -1.67E+00
p-value: 4.51E-08
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between PTH1R and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.67E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Knockout of Mettl3 reduces the translation efficiency of MSCs lineage allocator Parathyroid hormone 1 receptor (PTH1R), and disrupts the PTH-induced osteogenic and adipogenic responses in vivo.
Target Regulation Up regulation
Responsed Disease Osteoporosis ICD-11: FB83.1
 Disease Info 
Pathway Response Parathyroid hormone synthesis, secretion and action hsa04928
Cell Process Adipogenesis
In-vivo Model Mettl3fl/+ mice with C57BL6/J background were generated using CRISPR-Cas9 systems.
Low bone mass disorder [ICD-11: FB83]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Knockout of Mettl3 reduces the translation efficiency of MSCs lineage allocator Parathyroid hormone 1 receptor (PTH1R), and disrupts the PTH-induced osteogenic and adipogenic responses in vivo.
Responsed Disease Osteoporosis [ICD-11: FB83.1]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Parathyroid hormone synthesis, secretion and action hsa04928
Cell Process Adipogenesis
In-vivo Model Mettl3fl/+ mice with C57BL6/J background were generated using CRISPR-Cas9 systems.
References
Ref 1 Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun. 2018 Nov 14;9(1):4772. doi: 10.1038/s41467-018-06898-4.