m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00359)
Target Name PCNA-interacting partner (PARPBP)
Synonyms
PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP; C12orf48; PARI
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Gene Name PARPBP
Chromosomal Location 12q23.2
Family PARI family
Function
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
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Gene ID 55010
Uniprot ID
PARI_HUMAN
HGNC ID
HGNC:26074
Ensembl Gene ID
ENSG00000185480
KEGG ID
hsa:55010
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PARPBP can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary The study highlights a robust correlation between the level of cancer stemness and traits related to tumor heterogeneity, including the immune microenvironment, TMB, and the expression of m6A RNA methylation regulatory factors in colorectal cancer cells. A three-gene prognostic signature (PCNA-interacting partner (PARPBP), KNSTRN, and KIF2C) was explored together with specific clinical features to construct a nomogram, which was successfully validated in an external cohort.
Responsed Disease Colorectal cancer [ICD-11: 2B91]