m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00322)
Target Name DNA replication licensing factor MCM6 (MCM6)
Synonyms
p105MCM
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Gene Name MCM6
Chromosomal Location 2q21.3
Family MCM family
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
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Gene ID 4175
Uniprot ID
MCM6_HUMAN
HGNC ID
HGNC:6949
Ensembl Gene ID
ENSG00000076003
KEGG ID
hsa:4175
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MCM6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Liver Mus musculus
Treatment: Mettl3-deficient liver
Control: Wild type liver cells
 GSE197800
Regulation
logFC: 2.47E+00
p-value: 3.65E-08
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between MCM6 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.92E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In gastric cancer, several component molecules (e.g., MCM5, DNA replication licensing factor MCM6 (MCM6), etc.) of MYC target genes were mediated by METTL3 via altered m6A modification.
Target Regulation Up regulation
Responsed Disease Gastric cancer ICD-11: 2B72
 Disease Info 
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model GES-1 Normal Homo sapiens CVCL_EQ22
HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
MGC-803 Gastric mucinous adenocarcinoma Homo sapiens CVCL_5334
MKN45 Gastric adenocarcinoma Homo sapiens CVCL_0434
MKN74 Gastric tubular adenocarcinoma Homo sapiens CVCL_2791
pGCC (Primary GC cells)
SGC-7901 Gastric carcinoma Homo sapiens CVCL_0520
In-vivo Model A total of 2 × 106 GC cells were injected into the flank of nude mice in a 1:1 suspension of BD Matrigel (BD Biosciences) in phosphate-buffered saline (PBS) solution.
Gastric cancer [ICD-11: 2B72]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary In gastric cancer, several component molecules (e.g., MCM5, DNA replication licensing factor MCM6 (MCM6), etc.) of MYC target genes were mediated by METTL3 via altered m6A modification.
Responsed Disease Gastric cancer [ICD-11: 2B72]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model GES-1 Normal Homo sapiens CVCL_EQ22
HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
MGC-803 Gastric mucinous adenocarcinoma Homo sapiens CVCL_5334
MKN45 Gastric adenocarcinoma Homo sapiens CVCL_0434
MKN74 Gastric tubular adenocarcinoma Homo sapiens CVCL_2791
pGCC (Primary GC cells)
SGC-7901 Gastric carcinoma Homo sapiens CVCL_0520
In-vivo Model A total of 2 × 106 GC cells were injected into the flank of nude mice in a 1:1 suspension of BD Matrigel (BD Biosciences) in phosphate-buffered saline (PBS) solution.
References
Ref 1 METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway. Front Oncol. 2020 Feb 26;10:115. doi: 10.3389/fonc.2020.00115. eCollection 2020.