m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00311)
Target Name Krueppel-like factor 5 (KLF5)
Synonyms
Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2; BTEB2; CKLF; IKLF
    Click to Show/Hide
Gene Name KLF5
Chromosomal Location 13q22.1
Family krueppel C2H2-type zinc-finger protein family
Function
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
    Click to Show/Hide
Gene ID 688
Uniprot ID
KLF5_HUMAN
HGNC ID
HGNC:6349
Ensembl Gene ID
ENSG00000102554
KEGG ID
hsa:688
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KLF5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by FTO
Cell Line Cerebral cortex Mus musculus
Treatment: METTL3 (f/f, Emx1-cre) cerebral cortex
Control: Wild type cerebral cortex
 GSE154992
Regulation
logFC: -1.34E+00
p-value: 1.46E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary FTO expression significantly contributes to the phenotype conversion of VSMCs and the aortic dissecting aneurysm by the demethylation function (m6A), thereby providing a novel therapeutic target. Knockdown of FTO suppresses the p-GSK3-beta levels and Krueppel-like factor 5 (KLF5) expression regardless of AngII treatment.
Target Regulation Up regulation
Responsed Disease Aortic aneurysm or dissection ICD-11: BD50
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process DNA repair
Cell proliferation and migration
In-vitro Model VSMC (Human aortic vascular smooth muscle cells)
Aortic aneurysm or dissection [ICD-11: BD50]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary FTO expression significantly contributes to the phenotype conversion of VSMCs and the aortic dissecting aneurysm by the demethylation function (m6A), thereby providing a novel therapeutic target. Knockdown of FTO suppresses the p-GSK3-beta levels and Krueppel-like factor 5 (KLF5) expression regardless of AngII treatment.
Responsed Disease Aortic aneurysm or dissection [ICD-11: BD50]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process DNA repair
Cell proliferation and migration
In-vitro Model VSMC (Human aortic vascular smooth muscle cells)
References
Ref 1 Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5. Front Cardiovasc Med. 2020 Nov 20;7:592550. doi: 10.3389/fcvm.2020.592550. eCollection 2020.