m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00302)

Target Name	Transcription factor JunB (JUNB)
Synonyms	Transcription factor AP-1 subunit JunB Click to Show/Hide
Gene Name	JUNB
Chromosomal Location	19p13.13
Family	bZIP family; Jun subfamily
Function	Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). Click to Show/Hide
Gene ID	3726
Uniprot ID	JUNB_HUMAN
HGNC ID	HGNC:6205
KEGG ID	hsa:3726

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

JUNB can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	ARPE-19 cell line	Homo sapiens
Treatment: shMETTL3 ARPE-19 cells Control: shControl ARPE-19 cells		GSE202017
Regulation		logFC: -8.92E-01 p-value: 4.99E-05
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between JUNB and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 2.95E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	m6A methyltransferase METTL3 is indispensable for TGF-beta-induced EMT of lung cancer cells through the regulation of Transcription factor JunB (JUNB).
Target Regulation	Up regulation
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
Pathway Response	Cytokine-cytokine receptor interaction			hsa04060
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vitro Model	LC-2/ad	Lung adenocarcinoma	Homo sapiens	CVCL_1373

Wilms tumor 1-associating protein (WTAP) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by WTAP*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: WTAP-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: -8.45E-01 p-value: 6.62E-13
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	MeRIP-Seq of mRNAs of MCF7 with or without treated by TGF-beta showed that mRNA with upregulated m6A modification level after TGF-beta treatment were enriched in TGF-beta signaling pathway. Phosphorylated level of SMAD2 or SMAD3 induced by TGF-beta was impaired when WTAP was silenced. The m6A modification and mRNA level of Transcription factor JunB (JUNB), which is known as a cell cycle inhibitor, both were increased after induction of TGF-beta and decreased after knockdown of WTAP. Phosphorylated level of SMAD2 or SMAD3 induced by TGF-beta was impaired when WTAP was silenced.
Target Regulation	Up regulation
Pathway Response	TGF-beta signaling pathway			hsa04350
	Cell cycle			hsa04110
Cell Process	Arrest cell cycle at G1 phase

	Cell apoptosis
In-vitro Model	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	m6A methyltransferase METTL3 is indispensable for TGF-beta-induced EMT of lung cancer cells through the regulation of Transcription factor JunB (JUNB).
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Cytokine-cytokine receptor interaction			hsa04060
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vitro Model	LC-2/ad	Lung adenocarcinoma	Homo sapiens	CVCL_1373

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 4 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02143		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Metformin	Drug Info
Crosstalk ID: M6ACROT02156		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Metformin	Drug Info
Crosstalk ID: M6ACROT02169		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Osimertinib	Drug Info
Crosstalk ID: M6ACROT02182		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Osimertinib	Drug Info

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03379		Crosstalk Info
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Lung cancer	Disease Info
Drug	Gefitinib	Drug Info
Crosstalk ID: M6ACROT03392		Crosstalk Info
Regulated Target	Histone H3 lysine 4 monomethylation (H3K4me1)
Crosstalk relationship	Histone modification → m6A
Disease	Lung cancer	Disease Info
Drug	Gefitinib	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00302)

Transcription factor JunB (JUNB)

5-methylcytidine (m5C)

In total 8 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001791		Click to Show/Hide the Full List
mod site	chr19:12791744-12791745:+		[3]
Sequence	CGGAGCGGCCCCGCAGGGACCCTCCCCAGACCGCCTGGGCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22908
mod ID: M5CSITE001792		Click to Show/Hide the Full List
mod site	chr19:12792263-12792264:+		[4]
Sequence	CCCTGGGCGCTACCGGGGGGCCCCCGGCTGGGCCCGGGGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22909
mod ID: M5CSITE001793		Click to Show/Hide the Full List
mod site	chr19:12792264-12792265:+		[4]
Sequence	CCTGGGCGCTACCGGGGGGCCCCCGGCTGGGCCCGGGGGCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22910
mod ID: M5CSITE001794		Click to Show/Hide the Full List
mod site	chr19:12792265-12792266:+		[4]
Sequence	CTGGGCGCTACCGGGGGGCCCCCGGCTGGGCCCGGGGGCGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22911
mod ID: M5CSITE001795		Click to Show/Hide the Full List
mod site	chr19:12792266-12792267:+		[4]
Sequence	TGGGCGCTACCGGGGGGCCCCCGGCTGGGCCCGGGGGCGTC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22912
mod ID: M5CSITE001796		Click to Show/Hide the Full List
mod site	chr19:12792267-12792268:+		[4]
Sequence	GGGCGCTACCGGGGGGCCCCCGGCTGGGCCCGGGGGCGTCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22913
mod ID: M5CSITE001797		Click to Show/Hide the Full List
mod site	chr19:12792925-12792926:+		[3]
Sequence	ACCCTGGGACCTAGGGGCGCCGCAAACCACACTGGACTCCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22914
mod ID: M5CSITE001798		Click to Show/Hide the Full List
mod site	chr19:12793160-12793161:+		[3]
Sequence	GGGGACATTGGGAAGGGGACCCCCGCCCCCTGCCCTCCCCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m5C_site_22915

N6-methyladenosine (m6A)

In total 41 m6A sequence/site(s) in this target gene
mod ID: M6ASITE040058		Click to Show/Hide the Full List
mod site	chr19:12791488-12791489:+		[5]
Sequence	GCTCAGGCTGAGCGGCTGGGACCTTGAGAGCGGCCAGGCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; LCLs; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422902
mod ID: M6ASITE040059		Click to Show/Hide the Full List
mod site	chr19:12791742-12791743:+		[5]
Sequence	CCCGGAGCGGCCCCGCAGGGACCCTCCCCAGACCGCCTGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; fibroblasts; GM12878; LCLs; CD8T; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422903
mod ID: M6ASITE040060		Click to Show/Hide the Full List
mod site	chr19:12791753-12791754:+		[5]
Sequence	CCCGCAGGGACCCTCCCCAGACCGCCTGGGCCGCCCGGATG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422904
mod ID: M6ASITE040061		Click to Show/Hide the Full List
mod site	chr19:12791788-12791789:+		[5]
Sequence	CGGATGTGCACTAAAATGGAACAGCCCTTCTACCACGACGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hESC-HEK293T; HepG2; U2OS; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422905
mod ID: M6ASITE040062		Click to Show/Hide the Full List
mod site	chr19:12791865-12791866:+		[6]
Sequence	TGGCCTCTCTCTACACGACTACAAACTCCTGAAACCGAGCC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422906
mod ID: M6ASITE040063		Click to Show/Hide the Full List
mod site	chr19:12791869-12791870:+		[5]
Sequence	CTCTCTCTACACGACTACAAACTCCTGAAACCGAGCCTGGC
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; U2OS; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422907
mod ID: M6ASITE040064		Click to Show/Hide the Full List
mod site	chr19:12791878-12791879:+		[5]
Sequence	CACGACTACAAACTCCTGAAACCGAGCCTGGCGGTCAACCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; GM12878; LCLs; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422908
mod ID: M6ASITE040065		Click to Show/Hide the Full List
mod site	chr19:12791941-12791942:+		[5]
Sequence	AAAGCGCCTGGGGCTCGCGGACCCGGCCCAGAGGGCGGCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; GM12878; LCLs; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422909
mod ID: M6ASITE040066		Click to Show/Hide the Full List
mod site	chr19:12791994-12791995:+		[5]
Sequence	CTTTTCTGGTCAGGGCTCGGACACCGGCGCGTCTCTCAAGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422910
mod ID: M6ASITE040067		Click to Show/Hide the Full List
mod site	chr19:12792057-12792058:+		[7]
Sequence	CCTGATTGTCCCCAACAGCAACGGCGTGATCACGACGACGC
Motif Score	2.147845238
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422911
mod ID: M6ASITE040068		Click to Show/Hide the Full List
mod site	chr19:12792091-12792092:+		[5]
Sequence	ACGACGCCTACACCCCCGGGACAGTACTTTTACCCCCGCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; kidney; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422912
mod ID: M6ASITE040069		Click to Show/Hide the Full List
mod site	chr19:12792201-12792202:+		[7]
Sequence	CGGCTTTGTCAAAGCCCTGGACGATCTGCACAAGATGAACC
Motif Score	3.616982143
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422913
mod ID: M6ASITE040070		Click to Show/Hide the Full List
mod site	chr19:12792219-12792220:+		[5]
Sequence	GGACGATCTGCACAAGATGAACCACGTGACACCCCCCAACG
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422914
mod ID: M6ASITE040071		Click to Show/Hide the Full List
mod site	chr19:12792227-12792228:+		[6]
Sequence	TGCACAAGATGAACCACGTGACACCCCCCAACGTGTCCCTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422915
mod ID: M6ASITE040072		Click to Show/Hide the Full List
mod site	chr19:12792315-12792316:+		[6]
Sequence	CCCGGAGCCACCTCCCGTTTACACCAACCTCAGCAGCTACT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422916
mod ID: M6ASITE040073		Click to Show/Hide the Full List
mod site	chr19:12792380-12792381:+		[5]
Sequence	GCGCCGGGGCTGCCGTCGGGACCGGGAGCTCGTACCCGACG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; A549; U2OS; LCLs; MT4; H1299; MM6; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422917
mod ID: M6ASITE040074		Click to Show/Hide the Full List
mod site	chr19:12792421-12792422:+		[6]
Sequence	ACCACCATCAGCTACCTCCCACACGCGCCGCCCTTCGCCGG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422918
mod ID: M6ASITE040075		Click to Show/Hide the Full List
mod site	chr19:12792496-12792497:+		[5]
Sequence	GCCTCCACCTTCAAGGAGGAACCGCAGACCGTGCCGGAGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; MT4; MM6; CD4T; GSC-11; HEK293T; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422919
mod ID: M6ASITE040076		Click to Show/Hide the Full List
mod site	chr19:12792503-12792504:+		[5]
Sequence	CCTTCAAGGAGGAACCGCAGACCGTGCCGGAGGCGCGCAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; MT4; MM6; CD4T; GSC-11; HEK293T; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422920
mod ID: M6ASITE040077		Click to Show/Hide the Full List
mod site	chr19:12792555-12792556:+		[6]
Sequence	GCCGCCGGTGTCCCCCATCAACATGGAAGACCAAGAGCGCA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422922
mod ID: M6ASITE040078		Click to Show/Hide the Full List
mod site	chr19:12792564-12792565:+		[5]
Sequence	GTCCCCCATCAACATGGAAGACCAAGAGCGCATCAAAGTGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422923
mod ID: M6ASITE040079		Click to Show/Hide the Full List
mod site	chr19:12792603-12792604:+		[5]
Sequence	GGAGCGCAAGCGGCTGCGGAACCGGCTGGCGGCCACCAAGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; HEK293T; U2OS; H1A; H1B; fibroblasts; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_4942889; ENST00000302754.6
External Link	RMBase: m6A_site_422924
mod ID: M6ASITE040080		Click to Show/Hide the Full List
mod site	chr19:12792663-12792664:+		[5]
Sequence	GCGCATCGCGCGCCTGGAGGACAAGGTGAAGACGCTCAAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422925
mod ID: M6ASITE040081		Click to Show/Hide the Full List
mod site	chr19:12792745-12792746:+		[5]
Sequence	GAGCAGGTGGCCCAGCTCAAACAGAAGGTCATGACCCACGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; kidney; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422926
mod ID: M6ASITE040082		Click to Show/Hide the Full List
mod site	chr19:12792802-12792803:+		[5]
Sequence	CTGCTGCTTGGGGTCAAGGGACACGCCTTCTGAACGTCCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; kidney; liver; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422927
mod ID: M6ASITE040083		Click to Show/Hide the Full List
mod site	chr19:12792815-12792816:+		[7]
Sequence	TCAAGGGACACGCCTTCTGAACGTCCCCTGCCCCTTTACGG
Motif Score	2.925321429
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422928
mod ID: M6ASITE040084		Click to Show/Hide the Full List
mod site	chr19:12792836-12792837:+		[5]
Sequence	CGTCCCCTGCCCCTTTACGGACACCCCCTCGCTTGGACGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; brain; kidney; liver; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422929
mod ID: M6ASITE040085		Click to Show/Hide the Full List
mod site	chr19:12792852-12792853:+		[7]
Sequence	ACGGACACCCCCTCGCTTGGACGGCTGGGCACACGCCTCCC
Motif Score	3.616982143
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422930
mod ID: M6ASITE040086		Click to Show/Hide the Full List
mod site	chr19:12792862-12792863:+		[8]
Sequence	CCTCGCTTGGACGGCTGGGCACACGCCTCCCACTGGGGTCC
Motif Score	2.830589286
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422931
mod ID: M6ASITE040087		Click to Show/Hide the Full List
mod site	chr19:12792913-12792914:+		[5]
Sequence	CGGTGGGCACCCACCCTGGGACCTAGGGGCGCCGCAAACCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422932
mod ID: M6ASITE040088		Click to Show/Hide the Full List
mod site	chr19:12792930-12792931:+		[5]
Sequence	GGGACCTAGGGGCGCCGCAAACCACACTGGACTCCGGCCCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422933
mod ID: M6ASITE040089		Click to Show/Hide the Full List
mod site	chr19:12792933-12792934:+		[6]
Sequence	ACCTAGGGGCGCCGCAAACCACACTGGACTCCGGCCCTCCT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422934
mod ID: M6ASITE040090		Click to Show/Hide the Full List
mod site	chr19:12792940-12792941:+		[5]
Sequence	GGCGCCGCAAACCACACTGGACTCCGGCCCTCCTACCCTGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422935
mod ID: M6ASITE040091		Click to Show/Hide the Full List
mod site	chr19:12792980-12792981:+		[7]
Sequence	CGCCCAGTCCTTCCACCTCGACGTTTACAAGCCCCCCCTTC
Motif Score	2.839505952
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422936
mod ID: M6ASITE040092		Click to Show/Hide the Full List
mod site	chr19:12792986-12792987:+		[9]
Sequence	GTCCTTCCACCTCGACGTTTACAAGCCCCCCCTTCCACTTT
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422937
mod ID: M6ASITE040093		Click to Show/Hide the Full List
mod site	chr19:12793034-12793035:+		[5]
Sequence	ATGTTTTTTTTCTGCTGGAAACAGACTCGATTCATATTGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422938
mod ID: M6ASITE040094		Click to Show/Hide the Full List
mod site	chr19:12793038-12793039:+		[7]
Sequence	TTTTTTTCTGCTGGAAACAGACTCGATTCATATTGAATATA
Motif Score	3.319380952
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422939
mod ID: M6ASITE040095		Click to Show/Hide the Full List
mod site	chr19:12793076-12793077:+		[6]
Sequence	ATAATATATTTGTGTATTTAACAGGGAGGGGAAGAGGGGGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422940
mod ID: M6ASITE040096		Click to Show/Hide the Full List
mod site	chr19:12793144-12793145:+		[5]
Sequence	TGGTACTCAAGCCCGCGGGGACATTGGGAAGGGGACCCCCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422941
mod ID: M6ASITE040097		Click to Show/Hide the Full List
mod site	chr19:12793158-12793159:+		[5]
Sequence	GCGGGGACATTGGGAAGGGGACCCCCGCCCCCTGCCCTCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422942
mod ID: M6ASITE040098		Click to Show/Hide the Full List
mod site	chr19:12793206-12793207:+		[5]
Sequence	CACCGTACTGTGGAAAAGAAACACGCACTTAGTCTCTAAAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: m6A_site_422943

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000197		Click to Show/Hide the Full List
mod site	chr19:12792207-12792208:+		[10]
Sequence	TGTCAAAGCCCTGGACGATCTGCACAAGATGAACCACGTGA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000302754.6
External Link	RMBase: Nm_site_2786

Ref 1	The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB. Biochem Biophys Res Commun. 2020 Mar 26;524(1):150-155. doi: 10.1016/j.bbrc.2020.01.042. Epub 2020 Jan 22.
Ref 2	The crosstalk between RNA m(6)A epitranscriptome and TGFBeta signaling pathway contributes to the arrest of cell cycle. Gene. 2020 May 15;738:144483. doi: 10.1016/j.gene.2020.144483. Epub 2020 Feb 15.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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