m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00281)
Target Name Putative heat shock 70 kDa protein 7 (HSPA7)
Synonyms
Heat shock 70 kDa protein B; HSP70B
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Gene Name HSPA7
Chromosomal Location 1q23.3
Family heat shock protein 70 family
Uniprot ID
HSP77_HUMAN
HGNC ID
HGNC:5240
KEGG ID
#N/A
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HSPA7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma [ICD-11: 2A00.00]
Responsed Drug Pembrolizumab Approved
 Drug Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
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Pembrolizumab [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
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Nivolumab [Phase 2]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response []
Response Summary Putative heat shock 70 kDa protein 7 (HSPA7) promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells in vitro and in clinical glioblastoma tumor samples. HSPA7 is expected to predict the ability of PD-1 inhibitors to respond to treatment in glioblastoma.
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
In-vitro Model ()
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