m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00257)
Target Name Forkhead box protein D1 (FOXD1)
Synonyms
Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4; FKHL8; FREAC4
    Click to Show/Hide
Gene Name FOXD1
Chromosomal Location 5q13.2
Function
Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes.
    Click to Show/Hide
Gene ID 2297
Uniprot ID
FOXD1_HUMAN
HGNC ID
HGNC:3802
Ensembl Gene ID
ENSG00000251493
KEGG ID
hsa:2297
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FOXD1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line LX2 cell line Homo sapiens
Treatment: shMETTL3 LX2 cells
Control: shLuc LX2 cells
 GSE207909
Regulation
logFC: 8.07E-01
p-value: 2.88E-13
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between FOXD1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.40E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 contributes to renal ischemia-reperfusion injury by regulating Forkhead box protein D1 (FOXD1) methylation. When METTL3 was inhibited, m6A levels were accordingly decreased and cell apoptosis was suppressed in the H/R in vitro model. Based on MeRIP sequencing, transcription factor activating enhancer binding protein 2-alpha (tfap2a), cytochrome P-450 1B1 (cyp1b1), and forkhead box D1 (foxd1) were significantly differentially expressed, as was m6A, which is involved in the negative regulation of cell proliferation and kidney development.
Target Regulation Down regulation
Responsed Disease Injury of kidney ICD-11: NB92.0
 Disease Info 
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model NRK-52E Normal Rattus norvegicus CVCL_0468
In-vivo Model Rats were anesthetized and incised through the midline of the abdomen, and the left renal vertebral arch and arteries were blocked for 45 min, thereby resulting in left kidney ischemia. At the same time, the right kidney was removed, further aggravating the degree of left kidney injury.
Urinary/pelvic organs injury [ICD-11: NB92]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 contributes to renal ischemia-reperfusion injury by regulating Forkhead box protein D1 (FOXD1) methylation. When METTL3 was inhibited, m6A levels were accordingly decreased and cell apoptosis was suppressed in the H/R in vitro model. Based on MeRIP sequencing, transcription factor activating enhancer binding protein 2-alpha (tfap2a), cytochrome P-450 1B1 (cyp1b1), and forkhead box D1 (foxd1) were significantly differentially expressed, as was m6A, which is involved in the negative regulation of cell proliferation and kidney development.
Responsed Disease Injury of kidney [ICD-11: NB92.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model NRK-52E Normal Rattus norvegicus CVCL_0468
In-vivo Model Rats were anesthetized and incised through the midline of the abdomen, and the left renal vertebral arch and arteries were blocked for 45 min, thereby resulting in left kidney ischemia. At the same time, the right kidney was removed, further aggravating the degree of left kidney injury.
References
Ref 1 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.