m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00248)
Target Name Protein C-ets-1 (ETS1)
Synonyms
p54; EWSR2
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Gene Name ETS1
Chromosomal Location 11q24.3
Family ETS family
Function
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
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Gene ID 2113
Uniprot ID
ETS1_HUMAN
HGNC ID
HGNC:3488
Ensembl Gene ID
ENSG00000134954
KEGG ID
hsa:2113
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ETS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Wilms tumor 1-associating protein (WTAP) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by WTAP
Cell Line mice hepatocyte Mus musculus
Treatment: Wtap Hknockout mice hepatocyte
Control: Wtap flox/flox mice hepatocyte
 GSE168850
Regulation
logFC: 1.11E+00
p-value: 3.10E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary WTAP-guided m6A modification contributes to the progression of Hepatocellular carcinoma cells via the HuR-Protein C-ets-1 (ETS1)-p21/p27 axis.
Target Regulation Down regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Cell cycle hsa04110
Cell Process Cell proliferation and tumor growth
Cell apoptosis
Arrest cell cycle at G2/M phase
In-vitro Model HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
QSG-7701 Endocervical adenocarcinoma Homo sapiens CVCL_6944
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model 3 × 106 treated HCC cells resuspended in 100 uL PBS were subcutaneously injected to the left flank of the mice, which were randomly divided into several groups. Tumor sizes were measured every 3 to 5 days.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary WTAP-guided m6A modification contributes to the progression of Hepatocellular carcinoma cells via the HuR-Protein C-ets-1 (ETS1)-p21/p27 axis.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Cell Process Cell proliferation and tumor growth
Cell apoptosis
Arrest cell cycle at G2/M phase
In-vitro Model HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
QSG-7701 Endocervical adenocarcinoma Homo sapiens CVCL_6944
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model 3 × 106 treated HCC cells resuspended in 100 uL PBS were subcutaneously injected to the left flank of the mice, which were randomly divided into several groups. Tumor sizes were measured every 3 to 5 days.
References
Ref 1 WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. Mol Cancer. 2019 Aug 22;18(1):127. doi: 10.1186/s12943-019-1053-8.