m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00229)
Target Name H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)
Synonyms
CBF5 homolog; Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1; NOLA4
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Gene Name DKC1
Chromosomal Location Xq28
Family pseudouridine synthase TruB family
Function
[Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.
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Gene ID 1736
Uniprot ID
DKC1_HUMAN
HGNC ID
HGNC:2890
Ensembl Gene ID
ENSG00000130826
KEGG ID
hsa:1736
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DKC1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
 GSE155612
Regulation
logFC: 6.68E-01
p-value: 1.04E-03
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between DKC1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.61E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Moreover, CircMEG3 inhibits the expression of H/ACA ribonucleoprotein complex subunit DKC1 (DKC1), a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. These observations provide important basic information for finding effective liver cancer therapeutic targets.
Target Regulation Down regulation
Responsed Disease Liver cancer ICD-11: 2C12
 Disease Info 
In-vitro Model Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
In-vivo Model Athymic BALB/c mice were injected with LCSC cells at the armpit area subcutaneously. The mice were then sacrificed and the tumors recovered.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Moreover, CircMEG3 inhibits the expression of H/ACA ribonucleoprotein complex subunit DKC1 (DKC1), a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. These observations provide important basic information for finding effective liver cancer therapeutic targets.
Responsed Disease Liver cancer [ICD-11: 2C12]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
In-vivo Model Athymic BALB/c mice were injected with LCSC cells at the armpit area subcutaneously. The mice were then sacrificed and the tumors recovered.
References
Ref 1 CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells. Mol Ther Nucleic Acids. 2020 Nov 17;23:310-323. doi: 10.1016/j.omtn.2020.11.009. eCollection 2021 Mar 5.