m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00183)
Target Name ATPase family AAA domain-containing protein 2 (ATAD2)
Synonyms
AAA nuclear coregulator cancer-associated protein; ANCCA; L16; PRO2000
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Gene Name ATAD2
Chromosomal Location 8q24.13
Family AAA ATPase family
Function
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
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Gene ID 29028
Uniprot ID
ATAD2_HUMAN
HGNC ID
HGNC:30123
Ensembl Gene ID
ENSG00000156802
KEGG ID
hsa:29028
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ATAD2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line DKO-1 cell line Homo sapiens
Treatment: METTL3 knockdown DKO-1 cell
Control: DKO-1 cell
 GSE182382
Regulation
logFC: 6.62E-01
p-value: 6.71E-03
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between ATAD2 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.75E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATPase family AAA domain-containing protein 2 (ATAD2), suggesting a potential therapeutic target for osteosarcoma treatment.
Target Regulation Up regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Cell Process Cell proliferation and invasion
Cell apoptosis
In-vitro Model HOS Osteosarcoma Homo sapiens CVCL_0312
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
Osteosarcoma [ICD-11: 2B51]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATPase family AAA domain-containing protein 2 (ATAD2), suggesting a potential therapeutic target for osteosarcoma treatment.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation and invasion
Cell apoptosis
In-vitro Model HOS Osteosarcoma Homo sapiens CVCL_0312
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
References
Ref 1 Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2. Biomed Pharmacother. 2020 May;125:109964. doi: 10.1016/j.biopha.2020.109964. Epub 2020 Feb 7.