m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00143)
Target Name Family with sequence similarity 225 member A (FAM225A)
Synonyms
FAM225A; C9orf109NCRNA00256ALINC00256A; chromosome 9 open reading frame 109; non-protein coding RNA 256A; long intergenic non-protein coding RNA 256A; family with sequence similarity 225, member A (non-protein coding); family with sequence similarity 225 member A (non-protein coding); DKFZp686A0127
    Click to Show/Hide
Gene Name FAM225A
Chromosomal Location 9q32
Family Long non-coding RNAs with FAM root symbol
Gene ID 286333
HGNC ID
HGNC:27855
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FAM225A can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: 1.41E+00
p-value: 1.18E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Family with sequence similarity 225 member A (FAM225A) functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin beta-3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote Nasopharyngeal carcinoma cell proliferation and invasion. FAM225A showed lower RNA stability after silencing of METTL3.
Target Regulation Up regulation
Responsed Disease Nasopharyngeal carcinoma ICD-11: 2B6B
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation and metastasis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CNE-1 Normal Homo sapiens CVCL_6888
CNE-2 Nasopharyngeal carcinoma Homo sapiens CVCL_6889
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
N2Tert (The human immortalized nasopharyngeal epithelial cell lines)
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model For the tumor growth model, 1 × 106 HNE1-Scrambled or HNE1-shFAM2225A 2# cells were injected into the axilla of the mice, and the tumor size was measured every 3 days.
Nasopharyngeal carcinoma [ICD-11: 2B6B]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Family with sequence similarity 225 member A (FAM225A) functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin beta-3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote Nasopharyngeal carcinoma cell proliferation and invasion. FAM225A showed lower RNA stability after silencing of METTL3.
Responsed Disease Nasopharyngeal carcinoma [ICD-11: 2B6B]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation and metastasis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CNE-1 Normal Homo sapiens CVCL_6888
CNE-2 Nasopharyngeal carcinoma Homo sapiens CVCL_6889
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
N2Tert (The human immortalized nasopharyngeal epithelial cell lines)
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model For the tumor growth model, 1 × 106 HNE1-Scrambled or HNE1-shFAM2225A 2# cells were injected into the axilla of the mice, and the tumor size was measured every 3 days.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 9 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05396
 Crosstalk Info 
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A)
Regulated Target Integrin subunit beta 3 (ITGB3)
Crosstalk relationship m6A → ncRNA
Disease Nasopharyngeal carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05942
 Crosstalk Info 
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A)
Regulated Target hsa-miR-590-3p
Crosstalk relationship m6A → ncRNA
Disease Cholangiocarcinoma
 Disease Info 
Crosstalk ID: M6ACROT05943
 Crosstalk Info 
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A)
Regulated Target MicroRNA 1275 (MIR1275)
Crosstalk relationship m6A → ncRNA
Disease Nasopharyngeal carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05944
 Crosstalk Info 
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A)
Regulated Target hsa-miR-590-3p
Crosstalk relationship m6A → ncRNA
Disease Hepatocellular carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05945
 Crosstalk Info 
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A)
Regulated Target MicroRNA 1275 (MIR1275)
Crosstalk relationship m6A → ncRNA
Disease Hepatocellular carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05946
 Crosstalk Info 
Epigenetic Regulator hsa-miR-590-3p
Regulated Target Integrin subunit beta 3 (ITGB3)
Crosstalk relationship m6A → ncRNA
Disease Cholangiocarcinoma
 Disease Info 
Crosstalk ID: M6ACROT05947
 Crosstalk Info 
Epigenetic Regulator MicroRNA 1275 (MIR1275)
Regulated Target Integrin subunit beta 3 (ITGB3)
Crosstalk relationship m6A → ncRNA
Disease Nasopharyngeal carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05948
 Crosstalk Info 
Epigenetic Regulator hsa-miR-590-3p
Regulated Target Integrin subunit beta 3 (ITGB3)
Crosstalk relationship m6A → ncRNA
Disease Hepatocellular carcinoma
 Disease Info 
Crosstalk ID: M6ACROT05949
 Crosstalk Info 
Epigenetic Regulator MicroRNA 1275 (MIR1275)
Regulated Target Integrin subunit beta 3 (ITGB3)
Crosstalk relationship m6A → ncRNA
Disease Hepatocellular carcinoma
 Disease Info 
References
Ref 1 Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3. Cancer Res. 2019 Sep 15;79(18):4612-4626. doi: 10.1158/0008-5472.CAN-19-0799. Epub 2019 Jul 22.