m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00127)
Target Name microRNA 25 (MIR25)
Synonyms
MIR25; MIRN25; hsa-mir-25
    Click to Show/Hide
Gene Name MIR25
Chromosomal Location 7q22.1
Family MicroRNA MIR25/92 family
Gene ID 407014
HGNC ID
HGNC:31609
miRBase ID
MI0000082
Ensembl Gene ID
ENSG00000207547
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR25 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Cigarette smoke-induced microRNA 25 (MIR25) excessive maturation via m6A modification promotes the development and progression of pancreatic cancer. This modification is catalyzed by overexpressed methyltransferase-like 3 (METTL3) due to hypomethylation of the METTL3 promoter also caused by CSC.
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
HPDE6c7 Normal Homo sapiens CVCL_0P38
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
In-vivo Model Mice (five in each group) were injected subcutaneously with 0.1 ml of cell suspension containing 2 × 106 cells in the back flank.
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Cigarette smoke-induced microRNA 25 (MIR25) excessive maturation via m6A modification promotes the development and progression of pancreatic cancer. This modification is catalyzed by overexpressed methyltransferase-like 3 (METTL3) due to hypomethylation of the METTL3 promoter also caused by CSC.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
HPDE6c7 Normal Homo sapiens CVCL_0P38
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
In-vivo Model Mice (five in each group) were injected subcutaneously with 0.1 ml of cell suspension containing 2 × 106 cells in the back flank.
References
Ref 1 Excessive miR-25-3p maturation via N(6)-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun. 2019 Apr 23;10(1):1858. doi: 10.1038/s41467-019-09712-x.