m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00121)
Target Name microRNA 335 (MIR335)
Synonyms
MIR335; MIRN335; hsa-mir-335
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Gene Name MIR335
Chromosomal Location 7q32.2
Family MicroRNAs
Gene ID 442904
HGNC ID
HGNC:31773
miRBase ID
MI0000816
Ensembl Gene ID
ENSG00000199043
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR335 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Mouse testis Mus musculus
Treatment: Mettl3 knockout mouse testis
Control: Mouse testis
 GSE99771
Regulation
logFC: 5.81E+00
p-value: 4.09E-06
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-mediated m6A methylation increases the maturation of microRNA 335 (MIR335), which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for acute ischemic stroke.
Target Regulation Up regulation
Responsed Disease Acute ischemic stroke ICD-11: 8B11
 Disease Info 
Cell Process RNA maturation
Cell apoptosis
In-vitro Model PC-12 Lung papillary adenocarcinoma Homo sapiens CVCL_S979
In-vivo Model After a median incision on the neck, the left common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA) were isolated. The left CCA and the ECA were ligated.
Acute ischemic stroke [ICD-11: 8B11]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-mediated m6A methylation increases the maturation of microRNA 335 (MIR335), which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for acute ischemic stroke.
Responsed Disease Acute ischemic stroke [ICD-11: 8B11]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process RNA maturation
Cell apoptosis
In-vitro Model PC-12 Lung papillary adenocarcinoma Homo sapiens CVCL_S979
In-vivo Model After a median incision on the neck, the left common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA) were isolated. The left CCA and the ECA were ligated.
References
Ref 1 Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke. Front Mol Neurosci. 2020 Jun 5;13:103. doi: 10.3389/fnmol.2020.00103. eCollection 2020.