m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00098)
Target Name HOXC13 antisense RNA (HOXC13-AS)
Synonyms
HOXC13-AS; HOXC-AS5; HOXC cluster antisense RNA 5 (non-protein coding); HOXC cluster antisense RNA 5
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Gene Name HOXC13-AS
Chromosomal Location 12q13.13
Family Antisense RNAs
Gene ID 100874366
HGNC ID
HGNC:43753
Ensembl Gene ID
ENSG00000249641
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HOXC13-AS can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary FTO-stabilized HOXC13 antisense RNA (HOXC13-AS) epigenetically up-regulated FZD6 and activated Wnt/beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT, suggesting HOXC13-AS as a potential target for cervical cancer treatment.
Target Regulation Up regulation
Responsed Disease Cervical cancer ICD-11: 2C77
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell proliferation
Cell invasion
Epithelial-mesenchymal transition
In-vitro Model C-33 A Cervical squamous cell carcinoma Homo sapiens CVCL_1094
C-4-I Cervical squamous cell carcinoma Homo sapiens CVCL_2253
Ect1/E6E7 Normal Homo sapiens CVCL_3679
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
Cervical cancer [ICD-11: 2C77]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary FTO-stabilized HOXC13 antisense RNA (HOXC13-AS) epigenetically up-regulated FZD6 and activated Wnt/beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT, suggesting HOXC13-AS as a potential target for cervical cancer treatment.
Responsed Disease Cervical cancer [ICD-11: 2C77]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell proliferation
Cell invasion
Epithelial-mesenchymal transition
In-vitro Model C-33 A Cervical squamous cell carcinoma Homo sapiens CVCL_1094
C-4-I Cervical squamous cell carcinoma Homo sapiens CVCL_2253
Ect1/E6E7 Normal Homo sapiens CVCL_3679
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
References
Ref 1 FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/Beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. J BUON. 2021 Jul-Aug;26(4):1279-1291.