m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00026)
Target Name hsa-miR-422a
Synonyms
hsa_miR_422a
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Gene Name hsa-miR-422a
miRBase ID
MIMAT0001339
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-422a can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc-D63785 m6A methylation to decrease hsa-miR-422a accumulation.
Target Regulation Up regulation
Responsed Disease Unspecific body region injury ICD-11: ND56
 Disease Info 
Cell Process Neuronal cell apoptosis
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Unspecific body region injury [ICD-11: ND56]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc-D63785 m6A methylation to decrease hsa-miR-422a accumulation.
Responsed Disease Unspecific body region injury [ICD-11: ND56]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Neuronal cell apoptosis
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
References
Ref 1 Oxygen glucose deprivation/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation. Cell Death Dis. 2020 Sep 30;11(9):816. doi: 10.1038/s41419-020-03021-8.