m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00020)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
mmu-miR-7212-5p
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Down-regulation of METTL3 promotes osteogenic processes both in vitro and in vivo, and this effect is recapitulated by the suppression of mmu-miR-7212-5p maturation. miR-7212-5p inhibits osteoblast differentiation in MC3T3-E1 cells by targeting FGFR3. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Unspecific body region injury | ICD-11: ND56 | ||
| Cell Process | Cell differentiation | |||
| In-vitro Model | MC3T3-E1 | Normal | Mus musculus | CVCL_0409 |
| In-vivo Model | A longitudinal incision was made on the skin and the muscles were separated to expose the femur. A transverse osteotomy was performed in the mid-diaphysis of the femur, and the bones were stabilized by inserting a 23-gauge intramedullary needle. Equal amounts (100 uL) of phosphate-buffered saline (PBS), plasmid METTL3 and agomiR-7212-5p (10 mg/kg body weight) were locally injected into the femoral fracture site. | |||
Unspecific body region injury [ICD-11: ND56]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Down-regulation of METTL3 promotes osteogenic processes both in vitro and in vivo, and this effect is recapitulated by the suppression of mmu-miR-7212-5p maturation. miR-7212-5p inhibits osteoblast differentiation in MC3T3-E1 cells by targeting FGFR3. | |||
| Responsed Disease | Unspecific body region injury [ICD-11: ND56] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell differentiation | |||
| In-vitro Model | MC3T3-E1 | Normal | Mus musculus | CVCL_0409 |
| In-vivo Model | A longitudinal incision was made on the skin and the muscles were separated to expose the femur. A transverse osteotomy was performed in the mid-diaphysis of the femur, and the bones were stabilized by inserting a 23-gauge intramedullary needle. Equal amounts (100 uL) of phosphate-buffered saline (PBS), plasmid METTL3 and agomiR-7212-5p (10 mg/kg body weight) were locally injected into the femoral fracture site. | |||