m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG04309)
Name |
ON-01135
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Synonyms |
Amerliorex; CDK1 inhibitors, Onconova; Novonex analogs, Onconova; ON-01060; ON-01130; ON-01220; ON-01250; ON-01300; ON-01330; ON-01370; ON-01500; ON-01560; ON-01590; ON-01620; Cell cycle checkpoint activators (cytoprotection), Onconova; ON-01060 derivatives, Onconova; ON-01500 series, Onconova; ON-01910 analogs, Onconova; Styryl benzyl sulfones (cell cycle checkpoint activators), Onconova
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Status |
Preclinical
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TTD Drug ID |
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cyclin-dependent kinase 1 (CDK1)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for ON-01135. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ON-01135 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). | [1], [2] | ||
Protein virilizer homolog (VIRMA)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for ON-01135. The Protein virilizer homolog (VIRMA) has potential in affecting the response of ON-01135 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). | [2], [3] | ||
References