m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG04129)
Name
WT1-targeted autologous dendritic cell vaccine
Synonyms
WT1-targeted autologous dendritic cell vaccine (cancer)
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Status
Phase 2
TTD Drug ID
D02MLO
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Wilms tumor protein (WT1)
ETS-related transcription factor Elf-3 (ELF3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Wilms tumor protein (WT1) is a therapeutic target for WT1-targeted autologous dendritic cell vaccine. The ETS-related transcription factor Elf-3 (ELF3) has potential in affecting the response of WT1-targeted autologous dendritic cell vaccine through regulating the expression of Wilms tumor protein (WT1). [1], [2]
References
Ref 1 Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy. PLoS One. 2019 May 31;14(5):e0216788. doi: 10.1371/journal.pone.0216788. eCollection 2019.
Ref 2 Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. doi: 10.1182/blood-2007-08-108241. Epub 2007 Sep 17.