m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG04110)
Name
AZX-100
Status
Phase 2
TTD Drug ID
D09IGR
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Heat shock protein beta-1 (HSPB1)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heat shock protein beta-1 (HSPB1) is a therapeutic target for AZX-100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZX-100 through regulating the expression of Heat shock protein beta-1 (HSPB1). [1], [2]
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heat shock protein beta-1 (HSPB1) is a therapeutic target for AZX-100. The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of AZX-100 through regulating the expression of Heat shock protein beta-1 (HSPB1). [1], [2]
References
Ref 1 Modification of N6-methyladenosine RNA methylation on heat shock protein expression. PLoS One. 2018 Jun 14;13(6):e0198604. doi: 10.1371/journal.pone.0198604. eCollection 2018.
Ref 2 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095.