m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG04062)
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Erbb2 tyrosine kinase receptor (HER2)
Fat mass and obesity-associated protein (FTO)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER-2-targeting CAR T Cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER-2-targeting CAR T Cells through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). | [1], [2] | ||
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER-2-targeting CAR T Cells. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of HER-2-targeting CAR T Cells through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). | [2], [3] | ||
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