m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG04046)
Name
UshStat
Synonyms
Myosin 7A gene therapy (Usher syndrome 1B, LentiVector), Oxford BioMedica; Myosin VIIA gene therapy (Usher syndrome 1B, LentiVector), Oxford BioMedica
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Status
Phase 1/2
TTD Drug ID
D0YO5Z
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Myosin-7 (MYH7)
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Myosin-7 (MYH7) is a therapeutic target for UshStat. The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of UshStat through regulating the expression of Myosin-7 (MYH7). [1], [2]
References
Ref 1 YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy. Cell Biosci. 2021 Jul 15;11(1):132. doi: 10.1186/s13578-021-00649-7.
Ref 2 Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. doi: 10.1038/nchembio.1223. Epub 2013 Mar 24.