m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03933)
Name
AIC100
Status
Phase 1
TTD Drug ID
DP0NU9
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Intercellular adhesion molecule ICAM-1 (ICAM1)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for AIC100. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AIC100 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for AIC100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AIC100 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [2], [3]
References
Ref 1 N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. doi: 10.1161/ATVBAHA.121.317295. Epub 2022 Mar 17.
Ref 2 National Cancer Institute Drug Dictionary (drug id 561410).
Ref 3 N(6)-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. Mol Ther Nucleic Acids. 2020 Jun 5;20:111-116. doi: 10.1016/j.omtn.2020.02.002. Epub 2020 Feb 11.