m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03876)
Name
LY3410738
Status
Phase 1
TTD Drug ID
D6AHO2
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Oxalosuccinate decarboxylase (IDH1)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Oxalosuccinate decarboxylase (IDH1) is a therapeutic target for LY3410738. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3410738 through regulating the expression of Oxalosuccinate decarboxylase (IDH1). [1], [2]
References
Ref 1 IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Cancer Cell. 2017 May 8;31(5):619-620. doi: 10.1016/j.ccell.2017.04.001.
Ref 2 2018 FDA drug approvals. Nat Rev Drug Discov. 2019 Feb;18(2):85-89. doi: 10.1038/d41573-019-00014-x.