m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03715)
Name
(D-Arg)(9)-p19(ARF) 26-44 peptide
Status
Investigative
TTD Drug ID
D01FSW
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Forkhead box protein M1 (FOXM1)
RNA demethylase ALKBH5 (ALKBH5)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Forkhead box protein M1 (FOXM1) is a therapeutic target for (D-Arg)(9)-p19(ARF) 26-44 peptide. The RNA demethylase ALKBH5 (ALKBH5) has potential in affecting the response of (D-Arg)(9)-p19(ARF) 26-44 peptide through regulating the expression of Forkhead box protein M1 (FOXM1). [1], [2]
Wilms tumor 1-associating protein (WTAP)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Forkhead box protein M1 (FOXM1) is a therapeutic target for (D-Arg)(9)-p19(ARF) 26-44 peptide. The Wilms tumor 1-associating protein (WTAP) has potential in affecting the response of (D-Arg)(9)-p19(ARF) 26-44 peptide through regulating the expression of Forkhead box protein M1 (FOXM1). [2], [3]
YTH domain-containing family protein 1 (YTHDF1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Forkhead box protein M1 (FOXM1) is a therapeutic target for (D-Arg)(9)-p19(ARF) 26-44 peptide. The YTH domain-containing family protein 1 (YTHDF1) has potential in affecting the response of (D-Arg)(9)-p19(ARF) 26-44 peptide through regulating the expression of Forkhead box protein M1 (FOXM1). [2], [4]
YTH domain-containing family protein 3 (YTHDF3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Forkhead box protein M1 (FOXM1) is a therapeutic target for (D-Arg)(9)-p19(ARF) 26-44 peptide. The YTH domain-containing family protein 3 (YTHDF3) has potential in affecting the response of (D-Arg)(9)-p19(ARF) 26-44 peptide through regulating the expression of Forkhead box protein M1 (FOXM1). [2], [5]
References
Ref 1 ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1. Cell Mol Biol Lett. 2022 Mar 12;27(1):26. doi: 10.1186/s11658-022-00329-5.
Ref 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1443).
Ref 3 N(6)-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m(6)A/FOXM1 axis. Bioengineered. 2022 Apr;13(4):7963-7973. doi: 10.1080/21655979.2021.2008218.
Ref 4 YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner. Cell Biosci. 2022 Feb 23;12(1):19. doi: 10.1186/s13578-022-00759-w.
Ref 5 m(6)A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts. Haematologica. 2022 Aug 1;107(8):1922-1927. doi: 10.3324/haematol.2021.279300.