m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03679)
Name
ISIS 5875
Status
Investigative
TTD Drug ID
D0A7AV
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
VCAM-1 messenger RNA (VCAM1 mRNA)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5875. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 5875 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [1], [2]
Insulin-like growth factor-binding protein 3 (IGFBP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5875. The Insulin-like growth factor-binding protein 3 (IGFBP3) has potential in affecting the response of ISIS 5875 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [2], [3]
References
Ref 1 N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. doi: 10.1161/ATVBAHA.121.317295. Epub 2022 Mar 17.
Ref 2 US patent application no. 5,843,738, Oligonucleotide modulation of cell adhesion.
Ref 3 IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression. Life Sci. 2021 Jan 15;265:118758. doi: 10.1016/j.lfs.2020.118758. Epub 2020 Nov 12.