m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG03516)
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Extracellular signal-regulated kinase 2 (ERK2)
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Extracellular signal-regulated kinase 2 (ERK2) is a therapeutic target for AEZS-131. The Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) has potential in affecting the response of AEZS-131 through regulating the expression of Extracellular signal-regulated kinase 2 (ERK2). | [1], [2] | ||
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Extracellular signal-regulated kinase 2 (ERK2) is a therapeutic target for AEZS-131. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of AEZS-131 through regulating the expression of Extracellular signal-regulated kinase 2 (ERK2). | [2], [3] | ||
YTH domain-containing family protein 3 (YTHDF3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Extracellular signal-regulated kinase 2 (ERK2) is a therapeutic target for AEZS-131. The YTH domain-containing family protein 3 (YTHDF3) has potential in affecting the response of AEZS-131 through regulating the expression of Extracellular signal-regulated kinase 2 (ERK2). | [2], [3] | ||
References