General Information of the Drug (ID: M6APDG03442)
Name
ATF-HI-8
Synonyms
urokinase/urinary trypsin inhibitor chimera, Nissin/Hamamatsu University
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Status
Investigative
TTD Drug ID
D05ABK
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Urokinase-type plasminogen activator (PLAU)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
Response Summary Urokinase-type plasminogen activator (PLAU) is a therapeutic target for ATF-HI-8. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ATF-HI-8 through regulating the expression of Urokinase-type plasminogen activator (PLAU). [1], [2]
References
Ref 1 METTL3 promotes colorectal cancer metastasis by stabilizing PLAU mRNA in an m6A-dependent manner. Biochem Biophys Res Commun. 2022 Jul 23;614:9-16. doi: 10.1016/j.bbrc.2022.04.141. Epub 2022 May 6.
Ref 2 Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator. Oncol Rep. 1999 May-Jun;6(3):523-6. doi: 10.3892/or.6.3.523.