m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03077)
Name
SPHINX31
Synonyms
1818389-84-2; N-(2-(4-(pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide; 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide; SPHINX 31;SPHINX-31; SCHEMBL17196904; BDBM221074; AMY11306; BCP30381; EX-A2804; s8810; BS-16147; HY-117661; CS-0066777; US9695160, 12; RXZ
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Status
Preclinical
Structure
Formula
C27H24F3N5O2
InChI
1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
InChIKey
VURLRACCOCGFDB-UHFFFAOYSA-N
PubChem CID
91972002
TTD Drug ID
D86ILE
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
SRSF protein kinase 1 (SRPK1)
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary SRSF protein kinase 1 (SRPK1) is a therapeutic target for SPHINX31. The Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) has potential in affecting the response of SPHINX31 through regulating the expression of SRSF protein kinase 1 (SRPK1). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary SRSF protein kinase 1 (SRPK1) is a therapeutic target for SPHINX31. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of SPHINX31 through regulating the expression of SRSF protein kinase 1 (SRPK1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary SRSF protein kinase 1 (SRPK1) is a therapeutic target for SPHINX31. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SPHINX31 through regulating the expression of SRSF protein kinase 1 (SRPK1). [1], [2]
RNA demethylase ALKBH5 (ALKBH5)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary SRSF protein kinase 1 (SRPK1) is a therapeutic target for SPHINX31. The RNA demethylase ALKBH5 (ALKBH5) has potential in affecting the response of SPHINX31 through regulating the expression of SRSF protein kinase 1 (SRPK1). [2], [3]
References
Ref 1 N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015 Feb 26;518(7540):560-4. doi: 10.1038/nature14234.
Ref 2 Piperazine derivatives for treating disorders. US9695160.
Ref 3 ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012 Nov 21.