General Information of the Drug (ID: M6APDG03028)
Name
Melatonin
Synonyms
Melatonex; Melatonin; Melatonine; Melovine; Circadin; JL5DK93RCL; Melatol; N-Acetyl-5-methoxytryptamine; N-acetyl-5-methoxy-tryptamine; 5-Methoxy-N-acetyltryptamine; 73-31-4; Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-; BRN 0205542; CCRIS 3472; CHEMBL45; EINECS 200-797-7; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; NSC 113928; UNII-JL5DK93RCL
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Status
Phase 4
Structure
Formula
C13H16N2O2
InChI
1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChIKey
DRLFMBDRBRZALE-UHFFFAOYSA-N
PubChem CID
896
INTEDE Drug ID
DR1018
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Melatonin. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Melatonin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Melatonin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Melatonin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. doi: 10.1124/dmd.104.002410. Epub 2004 Dec 22.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.